Transcription factors with Perturb-seq knockdown data for ENSG00000268403. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000268403 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000268403, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:9,264,697–9,266,230 | 195.3 kb | Distal (>10kb) Multiome | 703 | |
| chr11:9,313,980–9,315,407 | 146.0 kb | Distal (>10kb) Multiome | 997 | |
| chr11:9,363,967–9,364,851 | 96.2 kb | Distal (>10kb) Multiome | 1019 | |
| chr11:9,384,450–9,385,531 | 76.0 kb | Distal (>10kb) Multiome | 939 | |
| chr11:9,459,820–9,460,146 | 555 bp | At TSS | 228 | |
| chr11:9,460,209–9,461,643 | 169 bp | At TSS Multiome | 1040 | |
| chr11:9,572,794–9,575,580 | 112.8 kb | Distal (>10kb) Multiome | 1075 | |
| chr11:9,613,193–9,614,617 | 152.7 kb | Distal (>10kb) Multiome | 997 | |
| chr11:9,626,920–9,627,395 | 166.4 kb | Distal (>10kb) Multiome | 172 | |
| chr11:9,663,540–9,664,862 | 203.4 kb | Distal (>10kb) Multiome | 597 | |
| chr11:9,757,927–9,759,329 | 297.6 kb | Distal (>10kb) Multiome | 865 |
Genomic view of the ENSG00000268403 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.