Transcription factors with Perturb-seq knockdown data for ENSG00000268120. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000268120 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000268120, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,861,607–7,864,383 | 6.2 kb | Proximal (<10kb) | 348 | |
| chr19:7,868,454–7,870,252 | 308 bp | At TSS | 721 | |
| chr19:7,871,072–7,872,772 | 511 bp | At TSS | 487 | |
| chr19:7,873,962–7,875,061 | 3.4 kb | Proximal (<10kb) | 416 |
Genomic view of the ENSG00000268120 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.