Transcription factors with Perturb-seq knockdown data for ENSG00000267458. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267458 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267458, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:12,647,538–12,648,022 | 296.7 kb | Distal (>10kb) Multiome | 126 | |
| chr19:12,656,871–12,657,566 | 287.3 kb | Distal (>10kb) Multiome | 254 | |
| chr19:12,666,317–12,667,225 | 277.7 kb | Distal (>10kb) Multiome | 495 | |
| chr19:12,669,351–12,669,939 | 274.9 kb | Distal (>10kb) Multiome | 777 | |
| chr19:12,681,003–12,682,117 | 263.1 kb | Distal (>10kb) Multiome | 994 | |
| chr19:12,696,035–12,696,970 | 247.9 kb | Distal (>10kb) Multiome | 806 | |
| chr19:12,702,968–12,703,602 | 241.3 kb | Distal (>10kb) Multiome | 121 | |
| chr19:12,721,692–12,723,084 | 222.0 kb | Distal (>10kb) Multiome | 807 | |
| chr19:12,723,726–12,724,142 | 220.4 kb | Distal (>10kb) Multiome | 539 | |
| chr19:12,734,221–12,735,284 | 209.7 kb | Distal (>10kb) Multiome | 882 | |
| chr19:12,736,470–12,737,780 | 207.3 kb | Distal (>10kb) Multiome | 742 | |
| chr19:12,757,454–12,758,297 | 186.7 kb | Distal (>10kb) Multiome | 588 | |
| chr19:12,765,876–12,766,545 | 178.2 kb | Distal (>10kb) Multiome | 557 | |
| chr19:12,774,659–12,776,025 | 169.1 kb | Distal (>10kb) Multiome | 803 | |
| chr19:12,777,481–12,778,589 | 166.6 kb | Distal (>10kb) Multiome | 661 | |
| chr19:12,782,418–12,783,038 | 161.7 kb | Distal (>10kb) Multiome | 699 | |
| chr19:12,789,543–12,790,654 | 154.5 kb | Distal (>10kb) Multiome | 717 | |
| chr19:12,790,960–12,793,231 | 153.0 kb | Distal (>10kb) Multiome | 1015 | |
| chr19:12,793,340–12,794,240 | 150.8 kb | Distal (>10kb) Multiome | 808 | |
| chr19:12,801,120–12,802,290 | 142.6 kb | Distal (>10kb) Multiome | 901 | |
| chr19:12,806,212–12,806,984 | 137.9 kb | Distal (>10kb) Multiome | 827 | |
| chr19:12,825,565–12,826,186 | 118.7 kb | Distal (>10kb) Multiome | 436 | |
| chr19:12,832,484–12,833,101 | 111.9 kb | Distal (>10kb) Multiome | 970 | |
| chr19:12,833,638–12,834,477 | 110.5 kb | Distal (>10kb) Multiome | 310 | |
| chr19:12,838,114–12,838,869 | 106.0 kb | Distal (>10kb) Multiome | 377 | |
| chr19:12,840,071–12,841,485 | 103.6 kb | Distal (>10kb) Multiome | 391 | |
| chr19:12,847,633–12,848,090 | 96.7 kb | Distal (>10kb) Multiome | 535 | |
| chr19:12,867,327–12,868,022 | 76.8 kb | Distal (>10kb) Multiome | 315 | |
| chr19:12,872,968–12,873,990 | 71.1 kb | Distal (>10kb) Multiome | 263 | |
| chr19:12,880,834–12,881,875 | 63.0 kb | Distal (>10kb) Multiome | 656 | |
| chr19:12,884,836–12,886,381 | 59.1 kb | Distal (>10kb) Multiome | 717 | |
| chr19:12,890,614–12,891,603 | 53.5 kb | Distal (>10kb) Multiome | 841 | |
| chr19:12,913,054–12,913,584 | 31.1 kb | Distal (>10kb) Multiome | 373 | |
| chr19:12,919,018–12,919,719 | 25.1 kb | Distal (>10kb) Multiome | 732 | |
| chr19:12,933,441–12,934,086 | 10.7 kb | Distal (>10kb) Multiome | 789 | |
| chr19:12,937,426–12,939,166 | 6.0 kb | Proximal (<10kb) Multiome | 943 | |
| chr19:12,945,275–12,946,647 | 1.5 kb | Proximal (<10kb) Multiome | 1015 | |
| chr19:12,956,801–12,957,360 | 12.7 kb | Distal (>10kb) Multiome | 747 | |
| chr19:12,964,998–12,965,862 | 20.9 kb | Distal (>10kb) Multiome | 733 | |
| chr19:12,983,506–12,983,997 | 39.2 kb | Distal (>10kb) Multiome | 688 | |
| chr19:13,051,485–13,052,169 | 107.3 kb | Distal (>10kb) Multiome | 649 | |
| chr19:13,061,195–13,061,672 | 117.0 kb | Distal (>10kb) Multiome | 544 | |
| chr19:13,069,469–13,070,306 | 125.3 kb | Distal (>10kb) Multiome | 334 | |
| chr19:13,093,620–13,094,260 | 149.4 kb | Distal (>10kb) Multiome | 411 | |
| chr19:13,095,079–13,096,870 | 151.0 kb | Distal (>10kb) Multiome | 501 | |
| chr19:13,102,495–13,103,074 | 158.3 kb | Distal (>10kb) Multiome | 606 | |
| chr19:13,116,411–13,117,080 | 172.2 kb | Distal (>10kb) Multiome | 812 | |
| chr19:13,117,979–13,119,416 | 173.7 kb | Distal (>10kb) Multiome | 699 | |
| chr19:13,149,468–13,156,577 | 205.8 kb | Distal (>10kb) Multiome | 1333 | |
| chr19:13,162,579–13,165,523 | 220.3 kb | Distal (>10kb) Multiome | 1112 | |
| chr19:13,167,359–13,168,023 | 223.2 kb | Distal (>10kb) Multiome | 764 |
Genomic view of the ENSG00000267458 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.