Transcription factors with Perturb-seq knockdown data for ENSG00000267424. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267424 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267424, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:12,825,565–12,826,186 | at TSS | At TSS | 436 | |
| chr19:12,828,495–12,828,851 | 2.8 kb | Proximal (<10kb) | 216 | |
| chr19:12,832,484–12,833,101 | 6.8 kb | Proximal (<10kb) | 970 | |
| chr19:12,833,638–12,834,477 | 7.9 kb | Proximal (<10kb) | 310 | |
| chr19:12,835,367–12,835,598 | 9.7 kb | Proximal (<10kb) | 156 |
Genomic view of the ENSG00000267424 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.