Transcription factors with Perturb-seq knockdown data for ENSG00000267042. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267042 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267042, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,669,472–42,671,112 | 8.8 kb | Proximal (<10kb) | 230 | |
| chr17:42,673,584–42,674,462 | 5.5 kb | Proximal (<10kb) | 296 | |
| chr17:42,674,847–42,675,579 | 4.4 kb | Proximal (<10kb) | 194 | |
| chr17:42,676,055–42,678,790 | 1.2 kb | Proximal (<10kb) | 1070 | |
| chr17:42,679,005–42,680,519 | at TSS | At TSS | 654 | |
| chr17:42,681,360–42,681,672 | 1.4 kb | Proximal (<10kb) | 170 | |
| chr17:42,682,428–42,682,628 | 2.5 kb | Proximal (<10kb) | 491 | |
| chr17:42,682,736–42,683,400 | 2.8 kb | Proximal (<10kb) | 480 |
Genomic view of the ENSG00000267042 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.