Transcription factors with Perturb-seq knockdown data for ENSG00000267009. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267009 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267009, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:68,169,087–68,169,738 | 244.3 kb | Distal (>10kb) Multiome | 34 | |
| chr17:68,195,930–68,196,516 | 217.6 kb | Distal (>10kb) Multiome | 132 | |
| chr17:68,198,840–68,199,804 | 214.3 kb | Distal (>10kb) Multiome | 254 | |
| chr17:68,200,632–68,201,332 | 212.7 kb | Distal (>10kb) Multiome | 510 | |
| chr17:68,205,092–68,206,268 | 208.2 kb | Distal (>10kb) Multiome | 867 | |
| chr17:68,247,371–68,248,543 | 165.8 kb | Distal (>10kb) Multiome HiCAR | 986 | |
| chr17:68,291,089–68,292,878 | 121.3 kb | Distal (>10kb) Multiome | 972 | |
| chr17:68,413,573–68,414,186 | at TSS | At TSS | 153 | |
| chr17:68,456,319–68,458,376 | 44.0 kb | Distal (>10kb) Multiome | 914 | |
| chr17:68,511,401–68,513,461 | 98.6 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:68,599,584–68,601,475 | 186.7 kb | Distal (>10kb) Multiome | 707 |
Genomic view of the ENSG00000267009 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.