Transcription factors with Perturb-seq knockdown data for ENSG00000266869. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000266869 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000266869, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:71,675,065–71,675,809 | 173.2 kb | Distal (>10kb) Multiome | 150 | |
| chr14:71,764,455–71,765,204 | 83.8 kb | Distal (>10kb) Multiome | 75 | |
| chr14:71,776,411–71,777,708 | 71.7 kb | Distal (>10kb) Multiome | 230 | |
| chr14:71,855,509–71,855,697 | 6.9 kb | Proximal (<10kb) | 131 | |
| chr14:71,931,936–71,933,304 | 83.8 kb | Distal (>10kb) Multiome | 394 |
Genomic view of the ENSG00000266869 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.