Transcription factors with Perturb-seq knockdown data for ENSG00000266709. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000266709 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000266709, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:14,297,092–14,298,113 | 5.7 kb | Proximal (<10kb) | 567 | |
| chr17:14,298,503–14,298,726 | 5.1 kb | Proximal (<10kb) | 87 | |
| chr17:14,299,291–14,299,916 | 3.9 kb | Proximal (<10kb) | 432 | |
| chr17:14,300,397–14,303,082 | 770 bp | At TSS | 904 | |
| chr17:14,303,513–14,303,964 | at TSS | At TSS | 170 | |
| chr17:14,304,075–14,304,390 | 222 bp | At TSS | 143 | |
| chr17:14,308,769–14,310,537 | 4.9 kb | Proximal (<10kb) | 830 |
Genomic view of the ENSG00000266709 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.