Transcription factors with Perturb-seq knockdown data for ENSG00000266368. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000266368 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000266368, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:10,729,418–10,730,194 | 1247.7 kb | Distal (>10kb) Multiome HiCAR | 604 | |
| chr17:10,936,641–10,937,774 | 1040.4 kb | Distal (>10kb) Multiome HiCAR | 142 | |
| chr17:11,973,524–11,973,970 | 3.6 kb | Proximal (<10kb) | 64 | |
| chr17:11,986,045–11,987,265 | 8.8 kb | Proximal (<10kb) Multiome | 204 | |
| chr17:11,996,775–11,998,085 | 19.9 kb | Distal (>10kb) Multiome | 866 | |
| chr17:12,020,404–12,021,686 | 43.2 kb | Distal (>10kb) Multiome | 624 |
Genomic view of the ENSG00000266368 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.