Transcription factors with Perturb-seq knockdown data for ENSG00000266283. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000266283 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000266283, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:21,912,423–21,913,408 | 292.4 kb | Distal (>10kb) Multiome HiCAR | 73 | |
| chr18:21,933,673–21,935,412 | 270.5 kb | Distal (>10kb) Multiome | 335 | |
| chr18:21,990,759–21,991,669 | 214.0 kb | Distal (>10kb) Multiome | 354 | |
| chr18:22,020,051–22,020,863 | 184.8 kb | Distal (>10kb) Multiome | 228 | |
| chr18:22,026,039–22,027,477 | 178.3 kb | Distal (>10kb) Multiome | 321 | |
| chr18:22,079,674–22,080,842 | 125.1 kb | Distal (>10kb) Multiome | 105 | |
| chr18:22,093,896–22,094,823 | 110.8 kb | Distal (>10kb) Multiome | 197 | |
| chr18:22,101,589–22,102,358 | 103.3 kb | Distal (>10kb) Multiome | 40 | |
| chr18:22,110,470–22,110,946 | 94.5 kb | Distal (>10kb) Multiome | 169 | |
| chr18:22,158,498–22,160,201 | 45.9 kb | Distal (>10kb) Multiome | 129 | |
| chr18:22,167,956–22,172,162 | 36.0 kb | Distal (>10kb) Multiome | 792 | |
| chr18:22,200,389–22,201,108 | 4.1 kb | Proximal (<10kb) | 60 | |
| chr18:22,204,768–22,205,292 | at TSS | At TSS | 12 | |
| chr18:22,205,430–22,206,879 | 201 bp | At TSS | 28 | |
| chr18:22,207,725–22,208,086 | 2.5 kb | Proximal (<10kb) | 6 | |
| chr18:22,210,000–22,210,842 | 4.8 kb | Proximal (<10kb) | 42 | |
| chr18:22,210,980–22,211,374 | 5.8 kb | Proximal (<10kb) | 4 | |
| chr18:22,211,450–22,213,773 | 6.2 kb | Proximal (<10kb) | 112 | |
| chr18:22,215,228–22,217,784 | 10.0 kb | Proximal (<10kb) | 92 | |
| chr18:22,324,187–22,324,960 | 119.3 kb | Distal (>10kb) Multiome | 176 |
Genomic view of the ENSG00000266283 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.