Transcription factors with Perturb-seq knockdown data for ENSG00000265943. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000265943 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000265943, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:22,930,194–22,930,361 | 3.4 kb | Proximal (<10kb) | 99 | |
| chr18:22,932,872–22,934,106 | 263 bp | At TSS Multiome | 840 | |
| chr18:23,133,973–23,134,655 | 200.5 kb | Distal (>10kb) Multiome | 505 | |
| chr18:23,134,786–23,136,684 | 201.9 kb | Distal (>10kb) Multiome | 757 |
Genomic view of the ENSG00000265943 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.