Transcription factors with Perturb-seq knockdown data for ENSG00000264808. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000264808 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000264808, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:29,148,688–29,149,641 | 241.2 kb | Distal (>10kb) Multiome | 709 | |
| chr17:29,176,562–29,177,220 | 213.4 kb | Distal (>10kb) Multiome | 782 | |
| chr17:29,179,268–29,180,802 | 209.7 kb | Distal (>10kb) Multiome | 781 | |
| chr17:29,292,464–29,294,599 | 96.0 kb | Distal (>10kb) Multiome | 1029 | |
| chr17:29,369,902–29,370,603 | 20.1 kb | Distal (>10kb) Multiome | 305 | |
| chr17:29,389,919–29,391,325 | 107 bp | At TSS Multiome | 863 | |
| chr17:29,566,006–29,569,574 | 178.4 kb | Distal (>10kb) Multiome | 868 | |
| chr17:29,572,746–29,573,303 | 182.6 kb | Distal (>10kb) Multiome | 252 | |
| chr17:29,588,688–29,590,312 | 199.4 kb | Distal (>10kb) Multiome | 590 | |
| chr17:29,590,975–29,592,562 | 201.6 kb | Distal (>10kb) Multiome | 810 | |
| chr17:29,612,906–29,613,942 | 223.3 kb | Distal (>10kb) Multiome | 581 | |
| chr17:29,614,997–29,616,357 | 225.5 kb | Distal (>10kb) Multiome | 389 | |
| chr17:29,616,988–29,618,466 | 228.0 kb | Distal (>10kb) Multiome | 615 | |
| chr17:29,622,374–29,623,287 | 232.7 kb | Distal (>10kb) Multiome | 470 |
Genomic view of the ENSG00000264808 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.