Transcription factors with Perturb-seq knockdown data for ENSG00000263620. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000263620 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000263620, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:8,153,878–8,154,864 | 8.1 kb | Proximal (<10kb) | 644 | |
| chr17:8,155,928–8,157,418 | 5.6 kb | Proximal (<10kb) | 789 | |
| chr17:8,158,672–8,159,039 | 3.9 kb | Proximal (<10kb) | 350 | |
| chr17:8,162,377–8,163,907 | at TSS | At TSS | 637 | |
| chr17:8,164,190–8,164,640 | 1.2 kb | Proximal (<10kb) | 503 | |
| chr17:8,172,460–8,174,346 | 9.5 kb | Proximal (<10kb) | 1196 |
Genomic view of the ENSG00000263620 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.