Transcription factors with Perturb-seq knockdown data for ENSG00000262877. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000262877 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000262877, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,101,596–81,102,059 | 288.4 kb | Distal (>10kb) Multiome | 815 | |
| chr17:81,222,360–81,223,690 | 167.2 kb | Distal (>10kb) Multiome | 861 | |
| chr17:81,238,602–81,239,760 | 151.1 kb | Distal (>10kb) Multiome | 811 | |
| chr17:81,295,024–81,295,658 | 95.0 kb | Distal (>10kb) Multiome | 832 | |
| chr17:81,339,311–81,340,470 | 50.9 kb | Distal (>10kb) Multiome | 474 | |
| chr17:81,345,409–81,347,165 | 44.1 kb | Distal (>10kb) Multiome | 891 | |
| chr17:81,386,455–81,387,640 | 2.7 kb | Proximal (<10kb) | 603 | |
| chr17:81,393,141–81,395,575 | 3.7 kb | Proximal (<10kb) Multiome | 1168 | |
| chr17:81,396,480–81,397,832 | 7.1 kb | Proximal (<10kb) Multiome | 646 | |
| chr17:81,398,227–81,398,784 | 7.9 kb | Proximal (<10kb) | 281 | |
| chr17:81,399,276–81,400,125 | 9.0 kb | Proximal (<10kb) | 337 | |
| chr17:81,400,287–81,400,955 | 10.0 kb | Proximal (<10kb) | 392 | |
| chr17:81,481,258–81,481,865 | 91.2 kb | Distal (>10kb) Multiome | 348 | |
| chr17:81,483,927–81,484,829 | 94.1 kb | Distal (>10kb) Multiome | 828 | |
| chr17:81,487,690–81,488,371 | 97.7 kb | Distal (>10kb) Multiome | 721 | |
| chr17:81,511,887–81,515,656 | 122.6 kb | Distal (>10kb) Multiome | 1116 | |
| chr17:81,518,632–81,519,878 | 129.2 kb | Distal (>10kb) Multiome | 617 | |
| chr17:81,551,821–81,553,314 | 162.8 kb | Distal (>10kb) Multiome | 845 | |
| chr17:81,636,404–81,637,301 | 246.7 kb | Distal (>10kb) Multiome | 946 | |
| chr17:81,666,251–81,667,166 | 276.3 kb | Distal (>10kb) Multiome | 901 | |
| chr17:81,683,344–81,684,556 | 293.6 kb | Distal (>10kb) Multiome | 926 |
Genomic view of the ENSG00000262877 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.