Transcription factors with Perturb-seq knockdown data for ENSG00000262768. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000262768 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000262768, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:79,794,074–79,794,281 | 6.3 kb | Proximal (<10kb) | 79 | |
| chr17:79,796,576–79,798,566 | 2.0 kb | Proximal (<10kb) | 897 | |
| chr17:79,800,514–79,801,509 | at TSS | At TSS | 650 | |
| chr17:79,802,794–79,803,309 | 2.2 kb | Proximal (<10kb) | 320 | |
| chr17:79,808,745–79,808,984 | 8.1 kb | Proximal (<10kb) | 309 | |
| chr17:79,810,019–79,810,463 | 9.4 kb | Proximal (<10kb) | 392 |
Genomic view of the ENSG00000262768 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.