Transcription factors with Perturb-seq knockdown data for ENSG00000261140. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000261140 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000261140, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:2,223,095–2,224,285 | 348.5 kb | Distal (>10kb) Multiome HiCAR | 918 | |
| chr16:2,267,625–2,269,111 | 303.7 kb | Distal (>10kb) Multiome HiCAR | 1044 | |
| chr16:2,339,631–2,342,283 | 231.1 kb | Distal (>10kb) Multiome | 1129 | |
| chr16:2,428,282–2,429,948 | 142.7 kb | Distal (>10kb) Multiome | 827 | |
| chr16:2,459,524–2,460,612 | 111.9 kb | Distal (>10kb) Multiome | 670 | |
| chr16:2,467,565–2,468,324 | 104.1 kb | Distal (>10kb) Multiome | 450 | |
| chr16:2,470,913–2,472,223 | 100.6 kb | Distal (>10kb) Multiome | 427 | |
| chr16:2,473,455–2,476,127 | 96.8 kb | Distal (>10kb) Multiome | 719 | |
| chr16:2,501,124–2,501,877 | 70.5 kb | Distal (>10kb) Multiome | 471 | |
| chr16:2,513,006–2,514,809 | 58.2 kb | Distal (>10kb) Multiome | 818 | |
| chr16:2,531,456–2,533,080 | 39.8 kb | Distal (>10kb) Multiome | 883 | |
| chr16:2,537,433–2,538,433 | 34.1 kb | Distal (>10kb) Multiome | 498 | |
| chr16:2,603,176–2,603,939 | 31.5 kb | Distal (>10kb) Multiome HiCAR | 1066 | |
| chr16:2,673,059–2,673,910 | 101.6 kb | Distal (>10kb) Multiome | 471 | |
| chr16:2,682,205–2,683,006 | 110.6 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:2,720,741–2,721,896 | 149.3 kb | Distal (>10kb) Multiome | 758 | |
| chr16:2,751,637–2,753,398 | 180.6 kb | Distal (>10kb) Multiome | 1074 | |
| chr16:2,776,766–2,778,256 | 205.4 kb | Distal (>10kb) Multiome | 828 | |
| chr16:2,867,958–2,868,665 | 296.4 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the ENSG00000261140 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.