Transcription factors with Perturb-seq knockdown data for ENSG00000261098. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000261098 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000261098, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:107,017,268–107,019,724 | 297.0 kb | Distal (>10kb) Multiome | 627 | |
| chr11:107,214,758–107,215,955 | 101.0 kb | Distal (>10kb) Multiome | 165 | |
| chr11:107,272,015–107,273,250 | 43.6 kb | Distal (>10kb) Multiome | 172 | |
| chr11:107,293,778–107,294,384 | 22.1 kb | Distal (>10kb) Multiome | 141 | |
| chr11:107,396,653–107,398,090 | 81.2 kb | Distal (>10kb) Multiome | 156 | |
| chr11:107,457,301–107,458,292 | 141.6 kb | Distal (>10kb) Multiome | 636 | |
| chr11:107,565,178–107,566,246 | 249.4 kb | Distal (>10kb) Multiome | 741 | |
| chr11:107,589,994–107,592,189 | 275.1 kb | Distal (>10kb) Multiome | 484 |
Genomic view of the ENSG00000261098 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.