Transcription factors with Perturb-seq knockdown data for ENSG00000260971. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260971 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260971, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:56,453,155–56,454,023 | 24.1 kb | Distal (>10kb) Multiome | 234 | |
| chr1:56,477,272–56,478,021 | 49 bp | At TSS Multiome | 431 | |
| chr1:56,535,168–56,535,889 | 57.9 kb | Distal (>10kb) Multiome | 257 | |
| chr1:56,550,028–56,550,687 | 72.7 kb | Distal (>10kb) Multiome | 164 | |
| chr1:56,577,020–56,577,756 | 99.6 kb | Distal (>10kb) Multiome | 246 | |
| chr1:56,578,195–56,579,838 | 101.8 kb | Distal (>10kb) Multiome | 784 | |
| chr1:56,644,694–56,646,370 | 167.6 kb | Distal (>10kb) Multiome | 601 |
Genomic view of the ENSG00000260971 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.