Transcription factors with Perturb-seq knockdown data for ENSG00000260927. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260927 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260927, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:57,846,136–57,846,734 | 283.0 kb | Distal (>10kb) Multiome | 213 | |
| chr16:57,859,222–57,859,950 | 269.9 kb | Distal (>10kb) Multiome | 269 | |
| chr16:57,984,418–57,986,121 | 144.5 kb | Distal (>10kb) Multiome | 447 | |
| chr16:57,999,954–58,001,881 | 128.3 kb | Distal (>10kb) Multiome | 920 | |
| chr16:58,024,574–58,028,306 | 103.9 kb | Distal (>10kb) Multiome HiCAR | 1046 | |
| chr16:58,032,341–58,033,244 | 96.7 kb | Distal (>10kb) Multiome HiCAR | 283 | |
| chr16:58,122,003–58,122,198 | 7.3 kb | Proximal (<10kb) | 307 | |
| chr16:58,128,725–58,130,027 | 9 bp | At TSS Multiome | 1095 | |
| chr16:58,197,509–58,198,705 | 68.7 kb | Distal (>10kb) Multiome | 490 | |
| chr16:58,236,247–58,236,852 | 107.1 kb | Distal (>10kb) Multiome | 355 | |
| chr16:58,249,584–58,250,557 | 120.5 kb | Distal (>10kb) Multiome | 641 | |
| chr16:58,392,269–58,393,124 | 263.1 kb | Distal (>10kb) Multiome | 993 |
Genomic view of the ENSG00000260927 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.