Transcription factors with Perturb-seq knockdown data for ENSG00000260834. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260834 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260834, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:65,120,735–65,123,829 | 112.6 kb | Distal (>10kb) Multiome | 341 | |
| chr16:65,224,437–65,225,317 | 9.6 kb | Proximal (<10kb) | 63 | |
| chr16:65,226,014–65,226,686 | 8.2 kb | Proximal (<10kb) | 20 | |
| chr16:65,227,173–65,228,011 | 6.9 kb | Proximal (<10kb) | 29 | |
| chr16:65,229,855–65,230,158 | 4.8 kb | Proximal (<10kb) | 3 | |
| chr16:65,233,177–65,233,428 | 1.5 kb | Proximal (<10kb) | 2 | |
| chr16:65,233,530–65,234,013 | 919 bp | At TSS | 61 | |
| chr16:65,234,820–65,236,377 | 125 bp | At TSS Multiome | 257 | |
| chr16:65,318,705–65,319,215 | 84.0 kb | Distal (>10kb) Multiome | 118 | |
| chr16:66,269,911–66,271,163 | 1035.7 kb | Distal (>10kb) Multiome HiCAR | 588 |
Genomic view of the ENSG00000260834 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.