Transcription factors with Perturb-seq knockdown data for ENSG00000260711. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260711 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260711, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:91,509,196–91,511,114 | 249.3 kb | Distal (>10kb) Multiome | 1071 | |
| chr14:91,835,675–91,837,066 | 76.8 kb | Distal (>10kb) Multiome | 412 | |
| chr14:91,947,236–91,948,135 | 187.9 kb | Distal (>10kb) Multiome | 316 | |
| chr14:92,039,326–92,040,502 | 280.2 kb | Distal (>10kb) Multiome | 937 |
Genomic view of the ENSG00000260711 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.