Transcription factors with Perturb-seq knockdown data for ENSG00000260464. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260464 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260464, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:93,836,482–93,837,232 | 9.9 kb | Proximal (<10kb) | 8 | |
| chr1:93,837,563–93,837,725 | 9.4 kb | Proximal (<10kb) | 9 | |
| chr1:93,844,334–93,844,593 | 2.6 kb | Proximal (<10kb) | 254 | |
| chr1:93,845,985–93,846,892 | 280 bp | At TSS | 732 | |
| chr1:93,846,995–93,848,315 | at TSS | At TSS | 954 | |
| chr1:93,850,817–93,851,028 | 3.6 kb | Proximal (<10kb) | 57 |
Genomic view of the ENSG00000260464 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.