Transcription factors with Perturb-seq knockdown data for ENSG00000260400. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260400 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260400, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:68,406,245–68,407,662 | 291.2 kb | Distal (>10kb) Multiome | 898 | |
| chr10:68,471,473–68,472,528 | 226.6 kb | Distal (>10kb) Multiome | 831 | |
| chr10:68,527,011–68,528,012 | 171.0 kb | Distal (>10kb) Multiome | 912 | |
| chr10:68,559,963–68,561,065 | 138.1 kb | Distal (>10kb) Multiome | 777 | |
| chr10:68,600,036–68,600,760 | 98.0 kb | Distal (>10kb) Multiome | 755 | |
| chr10:68,720,659–68,721,908 | 22.7 kb | Distal (>10kb) Multiome | 939 | |
| chr10:68,826,917–68,827,679 | 128.8 kb | Distal (>10kb) Multiome | 577 | |
| chr10:68,900,541–68,901,785 | 202.7 kb | Distal (>10kb) Multiome | 1082 | |
| chr10:68,955,769–68,956,761 | 257.7 kb | Distal (>10kb) Multiome | 938 | |
| chr10:68,988,361–68,989,558 | 290.3 kb | Distal (>10kb) Multiome | 896 |
Genomic view of the ENSG00000260400 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.