Transcription factors with Perturb-seq knockdown data for ENSG00000260293. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260293 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260293, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:2,467,565–2,468,324 | 8.2 kb | Proximal (<10kb) | 450 | |
| chr16:2,468,439–2,469,135 | 7.4 kb | Proximal (<10kb) | 438 | |
| chr16:2,470,913–2,472,223 | 4.3 kb | Proximal (<10kb) | 427 | |
| chr16:2,473,455–2,476,127 | 430 bp | At TSS | 719 |
Genomic view of the ENSG00000260293 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.