Transcription factors with Perturb-seq knockdown data for ENSG00000260086. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260086 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260086, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:48,365,312–48,366,772 | 257.4 kb | Distal (>10kb) Multiome | 826 | |
| chr16:48,384,395–48,386,081 | 237.9 kb | Distal (>10kb) Multiome | 865 | |
| chr16:48,609,338–48,610,591 | 13.3 kb | Distal (>10kb) Multiome | 827 | |
| chr16:48,623,055–48,623,916 | 37 bp | At TSS Multiome | 714 | |
| chr16:48,630,227–48,630,899 | 6.8 kb | Proximal (<10kb) | 374 |
Genomic view of the ENSG00000260086 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.