Transcription factors with Perturb-seq knockdown data for ENSG00000260077. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260077 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260077, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:9,770,260–9,771,096 | 270.0 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr2:9,813,714–9,814,312 | 226.6 kb | Distal (>10kb) Multiome | 406 | |
| chr2:9,843,034–9,844,039 | 197.2 kb | Distal (>10kb) Multiome | 965 | |
| chr2:9,950,478–9,952,371 | 89.1 kb | Distal (>10kb) Multiome | 704 | |
| chr2:10,042,279–10,044,590 | 3.4 kb | Proximal (<10kb) Multiome | 999 | |
| chr2:10,057,234–10,058,147 | 17.1 kb | Distal (>10kb) Multiome | 504 | |
| chr2:10,079,477–10,080,916 | 39.4 kb | Distal (>10kb) Multiome | 381 | |
| chr2:10,097,234–10,097,850 | 56.9 kb | Distal (>10kb) Multiome | 372 | |
| chr2:10,120,050–10,120,940 | 79.7 kb | Distal (>10kb) Multiome | 1054 | |
| chr2:10,121,967–10,123,307 | 82.0 kb | Distal (>10kb) Multiome | 958 | |
| chr2:10,301,765–10,304,331 | 262.1 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the ENSG00000260077 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.