Transcription factors with Perturb-seq knockdown data for ENSG00000259959. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259959 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259959, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:47,836,414–47,838,176 | 7.4 kb | Proximal (<10kb) Multiome | 604 | |
| chr4:47,913,703–47,915,119 | 70.3 kb | Distal (>10kb) Multiome | 856 | |
| chr4:47,926,660–47,927,239 | 82.5 kb | Distal (>10kb) Multiome | 243 | |
| chr4:48,015,887–48,017,756 | 172.3 kb | Distal (>10kb) Multiome | 714 | |
| chr4:48,126,799–48,128,119 | 283.6 kb | Distal (>10kb) Multiome | 526 |
Genomic view of the ENSG00000259959 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.