Transcription factors with Perturb-seq knockdown data for ENSG00000259605. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259605 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259605, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:45,468,843–45,470,312 | 299.0 kb | Distal (>10kb) Multiome | 769 | |
| chr19:45,478,416–45,479,276 | 289.7 kb | Distal (>10kb) Multiome | 809 | |
| chr19:45,485,144–45,486,070 | 282.8 kb | Distal (>10kb) Multiome | 659 | |
| chr19:45,492,647–45,493,344 | 275.5 kb | Distal (>10kb) Multiome | 522 | |
| chr19:45,496,247–45,497,677 | 271.3 kb | Distal (>10kb) Multiome | 742 | |
| chr19:45,498,270–45,499,916 | 268.8 kb | Distal (>10kb) Multiome | 464 | |
| chr19:45,506,243–45,507,963 | 261.7 kb | Distal (>10kb) Multiome | 969 | |
| chr19:45,508,291–45,509,751 | 259.0 kb | Distal (>10kb) Multiome | 670 | |
| chr19:45,528,315–45,529,353 | 239.6 kb | Distal (>10kb) Multiome | 425 | |
| chr19:45,584,026–45,585,251 | 183.7 kb | Distal (>10kb) Multiome | 907 | |
| chr19:45,607,096–45,607,695 | 161.0 kb | Distal (>10kb) Multiome | 526 | |
| chr19:45,615,654–45,616,944 | 152.2 kb | Distal (>10kb) Multiome | 480 | |
| chr19:45,632,406–45,633,148 | 135.6 kb | Distal (>10kb) Multiome | 358 | |
| chr19:45,638,965–45,639,696 | 129.1 kb | Distal (>10kb) Multiome | 477 | |
| chr19:45,640,813–45,642,557 | 126.0 kb | Distal (>10kb) Multiome | 865 | |
| chr19:45,643,187–45,644,012 | 124.8 kb | Distal (>10kb) Multiome | 542 | |
| chr19:45,645,389–45,646,343 | 122.5 kb | Distal (>10kb) Multiome | 566 | |
| chr19:45,668,914–45,669,719 | 99.1 kb | Distal (>10kb) Multiome | 611 | |
| chr19:45,670,481–45,671,446 | 97.4 kb | Distal (>10kb) Multiome | 361 | |
| chr19:45,676,875–45,678,209 | 90.9 kb | Distal (>10kb) Multiome | 418 | |
| chr19:45,681,530–45,682,004 | 86.7 kb | Distal (>10kb) Multiome | 648 | |
| chr19:45,691,622–45,693,062 | 76.0 kb | Distal (>10kb) Multiome | 943 | |
| chr19:45,716,851–45,718,343 | 50.9 kb | Distal (>10kb) Multiome | 895 | |
| chr19:45,730,200–45,731,219 | 37.4 kb | Distal (>10kb) Multiome | 740 | |
| chr19:45,767,223–45,771,892 | 2.4 kb | Proximal (<10kb) Multiome | 1161 | |
| chr19:45,774,843–45,775,055 | 6.5 kb | Proximal (<10kb) | 76 | |
| chr19:45,779,258–45,780,150 | 11.2 kb | Distal (>10kb) Multiome | 445 | |
| chr19:45,792,338–45,793,273 | 24.5 kb | Distal (>10kb) Multiome | 609 | |
| chr19:45,815,484–45,818,073 | 47.5 kb | Distal (>10kb) Multiome | 623 | |
| chr19:45,862,559–45,864,765 | 94.8 kb | Distal (>10kb) Multiome | 976 | |
| chr19:45,881,480–45,883,645 | 114.5 kb | Distal (>10kb) Multiome | 990 | |
| chr19:45,885,092–45,887,294 | 118.2 kb | Distal (>10kb) Multiome | 913 | |
| chr19:45,901,212–45,903,471 | 134.5 kb | Distal (>10kb) Multiome | 780 | |
| chr19:45,952,967–45,953,485 | 184.7 kb | Distal (>10kb) Multiome | 329 | |
| chr19:45,973,761–45,974,227 | 205.7 kb | Distal (>10kb) Multiome | 201 | |
| chr19:45,994,774–45,995,740 | 226.9 kb | Distal (>10kb) Multiome | 660 | |
| chr19:46,014,941–46,015,784 | 247.0 kb | Distal (>10kb) Multiome | 220 | |
| chr19:46,016,414–46,017,078 | 248.5 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the ENSG00000259605 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.