Transcription factors with Perturb-seq knockdown data for ENSG00000259275. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259275 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259275, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:96,345,605–96,346,425 | 7.8 kb | Proximal (<10kb) | 274 | |
| chr15:96,347,231–96,347,881 | 6.4 kb | Proximal (<10kb) | 217 | |
| chr15:96,351,775–96,352,691 | 1.5 kb | Proximal (<10kb) | 207 | |
| chr15:96,353,728–96,354,827 | at TSS | At TSS | 469 | |
| chr15:96,356,710–96,357,467 | 2.5 kb | Proximal (<10kb) | 718 | |
| chr15:96,359,669–96,361,904 | 5.4 kb | Proximal (<10kb) | 452 | |
| chr15:96,362,858–96,363,630 | 8.6 kb | Proximal (<10kb) | 129 |
Genomic view of the ENSG00000259275 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.