Transcription factors with Perturb-seq knockdown data for ENSG00000259203. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259203 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259203, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:52,528,126–52,529,827 | 275.9 kb | Distal (>10kb) Multiome | 619 | |
| chr15:52,568,541–52,569,521 | 235.8 kb | Distal (>10kb) Multiome | 996 | |
| chr15:52,677,739–52,679,973 | 126.3 kb | Distal (>10kb) Multiome | 913 | |
| chr15:52,709,542–52,710,221 | 95.0 kb | Distal (>10kb) Multiome | 335 | |
| chr15:52,745,306–52,746,160 | 59.4 kb | Distal (>10kb) Multiome | 166 | |
| chr15:52,783,424–52,785,757 | 21.2 kb | Distal (>10kb) Multiome | 397 | |
| chr15:52,789,439–52,791,791 | 14.5 kb | Distal (>10kb) Multiome | 633 | |
| chr15:52,798,074–52,799,220 | 6.0 kb | Proximal (<10kb) Multiome | 184 | |
| chr15:52,803,586–52,804,285 | 606 bp | At TSS | 193 | |
| chr15:52,804,516–52,806,560 | 148 bp | At TSS Multiome | 322 | |
| chr15:52,810,350–52,810,829 | 5.5 kb | Proximal (<10kb) | 5 |
Genomic view of the ENSG00000259203 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.