Transcription factors with Perturb-seq knockdown data for ENSG00000259138. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259138 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259138, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:74,881,522–74,882,475 | 245.3 kb | Distal (>10kb) Multiome | 877 | |
| chr14:74,922,804–74,923,467 | 203.9 kb | Distal (>10kb) Multiome | 458 | |
| chr14:74,955,358–74,956,099 | 171.5 kb | Distal (>10kb) Multiome | 457 | |
| chr14:75,002,395–75,003,398 | 124.4 kb | Distal (>10kb) Multiome | 767 | |
| chr14:75,050,911–75,051,628 | 75.8 kb | Distal (>10kb) Multiome | 749 | |
| chr14:75,063,590–75,064,414 | 63.1 kb | Distal (>10kb) Multiome | 518 | |
| chr14:75,069,008–75,070,183 | 57.6 kb | Distal (>10kb) Multiome | 874 | |
| chr14:75,126,669–75,127,381 | 157 bp | At TSS Multiome | 888 | |
| chr14:75,176,098–75,177,235 | 49.7 kb | Distal (>10kb) Multiome | 975 | |
| chr14:75,258,653–75,259,760 | 132.0 kb | Distal (>10kb) Multiome | 840 | |
| chr14:75,276,919–75,277,969 | 150.0 kb | Distal (>10kb) Multiome | 731 | |
| chr14:75,278,060–75,280,702 | 151.4 kb | Distal (>10kb) Multiome | 928 | |
| chr14:75,293,606–75,295,425 | 167.1 kb | Distal (>10kb) Multiome HiCAR | 759 | |
| chr14:75,295,693–75,296,382 | 169.1 kb | Distal (>10kb) Multiome HiCAR | 471 | |
| chr14:75,419,070–75,419,695 | 292.4 kb | Distal (>10kb) Multiome | 358 |
Genomic view of the ENSG00000259138 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.