Transcription factors with Perturb-seq knockdown data for ENSG00000259132. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259132 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259132, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,973,681–22,973,857 | 8.4 kb | Proximal (<10kb) | 277 | |
| chr14:22,976,871–22,978,437 | 3.8 kb | Proximal (<10kb) | 680 | |
| chr14:22,980,658–22,980,953 | 1.3 kb | Proximal (<10kb) | 399 | |
| chr14:22,981,215–22,983,249 | at TSS | At TSS | 935 | |
| chr14:22,983,367–22,983,566 | 1.1 kb | Proximal (<10kb) | 271 | |
| chr14:22,986,661–22,986,881 | 4.4 kb | Proximal (<10kb) | 308 |
Genomic view of the ENSG00000259132 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.