Transcription factors with Perturb-seq knockdown data for ENSG00000259033. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259033 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259033, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:70,254,552–70,254,968 | 659 bp | At TSS | 228 | |
| chr14:70,255,084–70,255,684 | at TSS | At TSS | 99 | |
| chr14:70,359,242–70,360,086 | 104.1 kb | Distal (>10kb) Multiome | 1022 | |
| chr14:70,416,744–70,417,234 | 161.4 kb | Distal (>10kb) Multiome | 527 |
Genomic view of the ENSG00000259033 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.