Transcription factors with Perturb-seq knockdown data for ENSG00000258744. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258744 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258744, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:24,146,204–24,148,108 | 296.2 kb | Distal (>10kb) Multiome | 918 | |
| chr14:24,160,877–24,161,762 | 281.8 kb | Distal (>10kb) Multiome | 970 | |
| chr14:24,171,489–24,172,698 | 271.1 kb | Distal (>10kb) Multiome | 365 | |
| chr14:24,188,229–24,189,111 | 254.2 kb | Distal (>10kb) Multiome | 1074 | |
| chr14:24,195,072–24,196,365 | 247.4 kb | Distal (>10kb) Multiome | 1059 | |
| chr14:24,212,871–24,213,884 | 229.6 kb | Distal (>10kb) Multiome | 1036 | |
| chr14:24,215,523–24,216,241 | 227.0 kb | Distal (>10kb) Multiome | 955 | |
| chr14:24,231,706–24,233,147 | 210.4 kb | Distal (>10kb) Multiome | 1027 | |
| chr14:24,241,845–24,243,572 | 200.4 kb | Distal (>10kb) Multiome | 1077 | |
| chr14:24,270,770–24,271,924 | 171.6 kb | Distal (>10kb) Multiome | 1089 | |
| chr14:24,299,120–24,300,273 | 143.2 kb | Distal (>10kb) Multiome | 892 | |
| chr14:24,315,948–24,316,753 | 126.6 kb | Distal (>10kb) Multiome | 736 | |
| chr14:24,332,251–24,333,127 | 110.5 kb | Distal (>10kb) Multiome | 740 | |
| chr14:24,365,652–24,366,243 | 77.3 kb | Distal (>10kb) Multiome | 668 | |
| chr14:24,366,594–24,369,358 | 75.8 kb | Distal (>10kb) Multiome | 921 | |
| chr14:24,388,547–24,389,510 | 54.1 kb | Distal (>10kb) Multiome | 161 | |
| chr14:24,398,424–24,399,423 | 44.1 kb | Distal (>10kb) Multiome | 354 | |
| chr14:24,429,597–24,431,070 | 12.9 kb | Distal (>10kb) Multiome | 903 | |
| chr14:24,431,554–24,432,205 | 11.1 kb | Distal (>10kb) Multiome | 604 | |
| chr14:24,436,789–24,436,996 | 6.0 kb | Proximal (<10kb) | 265 | |
| chr14:24,441,935–24,443,373 | 381 bp | At TSS Multiome | 1072 | |
| chr14:24,481,599–24,482,121 | 38.8 kb | Distal (>10kb) Multiome | 593 |
Genomic view of the ENSG00000258744 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.