Transcription factors with Perturb-seq knockdown data for ENSG00000258661. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258661 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258661, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:36,646,734–36,648,858 | 9.9 kb | Proximal (<10kb) | 499 | |
| chr14:36,653,000–36,653,259 | 5.5 kb | Proximal (<10kb) | 70 | |
| chr14:36,655,705–36,656,663 | 2.1 kb | Proximal (<10kb) | 313 | |
| chr14:36,657,526–36,658,352 | 448 bp | At TSS | 107 | |
| chr14:36,658,495–36,659,134 | at TSS | At TSS | 113 | |
| chr14:36,660,899–36,662,390 | 2.1 kb | Proximal (<10kb) | 408 | |
| chr14:36,662,473–36,663,979 | 3.7 kb | Proximal (<10kb) | 279 | |
| chr14:36,666,238–36,667,190 | 7.4 kb | Proximal (<10kb) | 185 |
Genomic view of the ENSG00000258661 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.