Transcription factors with Perturb-seq knockdown data for ENSG00000258649. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258649 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258649, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:38,183,732–38,184,181 | 6.8 kb | Proximal (<10kb) | 47 | |
| chr14:38,187,587–38,187,817 | 3.2 kb | Proximal (<10kb) | 98 | |
| chr14:38,189,842–38,191,300 | 689 bp | At TSS Multiome | 214 | |
| chr14:38,191,369–38,191,603 | 387 bp | At TSS | 9 | |
| chr14:38,192,004–38,192,133 | 1.0 kb | Proximal (<10kb) | 2 | |
| chr14:38,192,240–38,192,820 | 1.5 kb | Proximal (<10kb) Multiome | 106 | |
| chr14:38,192,924–38,193,381 | 1.9 kb | Proximal (<10kb) | 2 | |
| chr14:38,195,855–38,196,465 | 4.9 kb | Proximal (<10kb) | 66 | |
| chr14:38,197,183–38,197,301 | 6.2 kb | Proximal (<10kb) | 61 | |
| chr14:38,198,901–38,199,478 | 7.9 kb | Proximal (<10kb) | 42 | |
| chr14:38,201,318–38,205,935 | 11.8 kb | Distal (>10kb) Multiome | 470 | |
| chr14:38,207,227–38,211,992 | 18.4 kb | Distal (>10kb) Multiome | 611 | |
| chr14:38,254,752–38,256,715 | 64.8 kb | Distal (>10kb) Multiome | 311 |
Genomic view of the ENSG00000258649 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.