Transcription factors with Perturb-seq knockdown data for ENSG00000258507. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258507 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258507, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:8,855,826–8,856,043 | 4.8 kb | Proximal (<10kb) | 65 | |
| chr4:8,857,204–8,857,659 | 3.2 kb | Proximal (<10kb) | 73 | |
| chr4:8,857,761–8,858,310 | 2.5 kb | Proximal (<10kb) | 47 | |
| chr4:8,858,416–8,858,762 | 2.1 kb | Proximal (<10kb) | 32 | |
| chr4:8,859,498–8,862,107 | at TSS | At TSS | 274 | |
| chr4:8,867,617–8,868,531 | 6.8 kb | Proximal (<10kb) | 58 |
Genomic view of the ENSG00000258507 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.