Transcription factors with Perturb-seq knockdown data for ENSG00000257921. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000257921 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000257921, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,765,020–57,765,720 | 6.9 kb | Proximal (<10kb) | 472 | |
| chr12:57,765,777–57,766,300 | 6.4 kb | Proximal (<10kb) | 235 | |
| chr12:57,766,452–57,767,514 | 5.1 kb | Proximal (<10kb) | 330 | |
| chr12:57,771,528–57,773,018 | at TSS | At TSS | 1006 | |
| chr12:57,782,579–57,783,204 | 9.9 kb | Proximal (<10kb) | 916 |
Genomic view of the ENSG00000257921 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.