Transcription factors with Perturb-seq knockdown data for ENSG00000257341. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000257341 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000257341, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:105,480,543–105,482,375 | 4.8 kb | Proximal (<10kb) | 784 | |
| chr14:105,485,648–105,486,379 | 818 bp | At TSS | 424 | |
| chr14:105,486,576–105,487,923 | at TSS | At TSS | 369 | |
| chr14:105,489,310–105,492,133 | 2.1 kb | Proximal (<10kb) | 1014 |
Genomic view of the ENSG00000257341 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.