Transcription factors with Perturb-seq knockdown data for ENSG00000254639. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000254639 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000254639, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:46,237,214–46,237,437 | 943 bp | At TSS | 427 | |
| chr11:46,237,806–46,238,447 | at TSS | At TSS | 520 | |
| chr11:46,238,964–46,239,736 | 583 bp | At TSS | 559 | |
| chr11:46,242,857–46,244,010 | 4.5 kb | Proximal (<10kb) | 900 | |
| chr11:46,247,683–46,247,877 | 9.3 kb | Proximal (<10kb) | 237 |
Genomic view of the ENSG00000254639 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.