Transcription factors with Perturb-seq knockdown data for ENSG00000254372. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000254372 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000254372, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:135,452,439–135,452,616 | 4.3 kb | Proximal (<10kb) | 145 | |
| chr8:135,456,036–135,459,111 | at TSS | At TSS | 758 | |
| chr8:135,463,097–135,463,253 | 6.1 kb | Proximal (<10kb) | 4 | |
| chr8:135,463,357–135,463,562 | 6.4 kb | Proximal (<10kb) | 16 | |
| chr8:135,463,675–135,463,921 | 6.7 kb | Proximal (<10kb) | 32 | |
| chr8:135,465,958–135,466,326 | 9.0 kb | Proximal (<10kb) | 103 |
Genomic view of the ENSG00000254372 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.