Transcription factors with Perturb-seq knockdown data for ENSG00000254339. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000254339 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000254339, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:112,772,170–112,773,182 | 1509.4 kb | Distal (>10kb) Multiome HiCAR | 248 | |
| chr8:113,046,042–113,047,133 | 1235.5 kb | Distal (>10kb) Multiome HiCAR | 193 | |
| chr8:114,281,583–114,282,523 | 96 bp | At TSS Multiome | 155 | |
| chr8:114,283,469–114,284,020 | 1.4 kb | Proximal (<10kb) | 52 | |
| chr8:114,284,139–114,284,637 | 2.1 kb | Proximal (<10kb) | 2 | |
| chr8:114,287,076–114,287,767 | 5.0 kb | Proximal (<10kb) | 108 | |
| chr8:114,289,145–114,289,667 | 7.1 kb | Proximal (<10kb) | 10 | |
| chr8:114,290,799–114,291,506 | 8.8 kb | Proximal (<10kb) | 113 |
Genomic view of the ENSG00000254339 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.