Transcription factors with Perturb-seq knockdown data for ENSG00000253252. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000253252 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000253252, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:8,891,982–8,894,021 | 288.9 kb | Distal (>10kb) Multiome | 613 | |
| chr8:8,963,219–8,963,764 | 219.0 kb | Distal (>10kb) Multiome | 278 | |
| chr8:9,002,478–9,003,402 | 179.6 kb | Distal (>10kb) Multiome | 894 | |
| chr8:9,057,454–9,058,557 | 124.4 kb | Distal (>10kb) Multiome | 293 | |
| chr8:9,101,993–9,102,949 | 80.1 kb | Distal (>10kb) Multiome | 546 | |
| chr8:9,123,903–9,124,447 | 58.3 kb | Distal (>10kb) Multiome | 32 | |
| chr8:9,150,157–9,151,970 | 31.8 kb | Distal (>10kb) Multiome | 725 | |
| chr8:9,182,861–9,183,028 | 342 bp | At TSS | 32 | |
| chr8:9,183,123–9,184,864 | 1.1 kb | Proximal (<10kb) Multiome | 265 | |
| chr8:9,296,640–9,298,063 | 114.6 kb | Distal (>10kb) Multiome HiCAR | 163 | |
| chr8:9,412,347–9,413,021 | 230.1 kb | Distal (>10kb) Multiome | 227 |
Genomic view of the ENSG00000253252 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.