Transcription factors with Perturb-seq knockdown data for ENSG00000251131. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000251131 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000251131, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:43,007,445–43,008,850 | 9.3 kb | Proximal (<10kb) | 862 | |
| chr5:43,010,087–43,010,939 | 7.2 kb | Proximal (<10kb) | 417 | |
| chr5:43,016,201–43,016,848 | 1.3 kb | Proximal (<10kb) | 194 | |
| chr5:43,017,299–43,018,875 | at TSS | At TSS | 870 | |
| chr5:43,018,997–43,019,167 | 853 bp | At TSS | 178 | |
| chr5:43,019,534–43,019,881 | 1.4 kb | Proximal (<10kb) | 325 | |
| chr5:43,020,015–43,020,316 | 1.9 kb | Proximal (<10kb) | 507 | |
| chr5:43,020,419–43,020,757 | 2.3 kb | Proximal (<10kb) | 302 | |
| chr5:43,024,186–43,024,558 | 6.0 kb | Proximal (<10kb) | 23 | |
| chr5:43,024,983–43,026,034 | 6.8 kb | Proximal (<10kb) | 130 | |
| chr5:43,026,256–43,026,606 | 8.1 kb | Proximal (<10kb) | 31 |
Genomic view of the ENSG00000251131 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.