Transcription factors with Perturb-seq knockdown data for ENSG00000251095. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000251095 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000251095, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:89,640,712–89,641,562 | 40.2 kb | Distal (>10kb) Multiome | 327 | |
| chr4:89,681,261–89,681,560 | at TSS | At TSS | 354 | |
| chr4:89,685,452–89,685,645 | 3.9 kb | Proximal (<10kb) | 7 | |
| chr4:89,836,019–89,838,409 | 155.8 kb | Distal (>10kb) Multiome | 559 |
Genomic view of the ENSG00000251095 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.