Transcription factors with Perturb-seq knockdown data for ENSG00000250383. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000250383 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000250383, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:108,824,945–108,825,643 | 5.1 kb | Proximal (<10kb) | 32 | |
| chr5:108,827,204–108,827,436 | 3.4 kb | Proximal (<10kb) | 76 | |
| chr5:108,830,334–108,830,469 | 320 bp | At TSS | 2 | |
| chr5:108,830,577–108,831,179 | at TSS | At TSS | 187 |
Genomic view of the ENSG00000250383 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.