Transcription factors with Perturb-seq knockdown data for ENSG00000250046. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000250046 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000250046, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:112,509,466–112,511,736 | 195.8 kb | Distal (>10kb) Multiome | 299 | |
| chr4:112,514,488–112,516,977 | 190.1 kb | Distal (>10kb) Multiome | 586 | |
| chr4:112,522,782–112,524,704 | 182.8 kb | Distal (>10kb) Multiome | 638 | |
| chr4:112,636,483–112,637,927 | 69.6 kb | Distal (>10kb) Multiome | 891 | |
| chr4:112,642,445–112,646,414 | 61.1 kb | Distal (>10kb) Multiome | 296 | |
| chr4:112,647,946–112,649,404 | 57.9 kb | Distal (>10kb) Multiome | 235 | |
| chr4:112,704,982–112,705,792 | 1.0 kb | Proximal (<10kb) | 134 | |
| chr4:112,706,097–112,706,856 | 340 bp | At TSS Multiome | 313 | |
| chr4:112,759,125–112,759,682 | 52.7 kb | Distal (>10kb) Multiome HiCAR | 195 | |
| chr4:112,817,726–112,818,715 | 111.4 kb | Distal (>10kb) Multiome | 463 | |
| chr4:112,860,814–112,861,553 | 154.3 kb | Distal (>10kb) Multiome | 167 | |
| chr4:112,979,338–112,980,523 | 273.2 kb | Distal (>10kb) Multiome | 216 |
Genomic view of the ENSG00000250046 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.