Transcription factors with Perturb-seq knockdown data for ENSG00000249426. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000249426 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000249426, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:118,646,987–118,648,343 | 137.6 kb | Distal (>10kb) Multiome | 193 | |
| chr5:118,791,921–118,792,538 | 6.5 kb | Proximal (<10kb) | 155 | |
| chr5:118,951,671–118,953,627 | 167.0 kb | Distal (>10kb) Multiome | 243 | |
| chr5:118,987,706–118,989,045 | 203.0 kb | Distal (>10kb) Multiome | 941 | |
| chr5:119,070,182–119,071,897 | 285.6 kb | Distal (>10kb) Multiome | 975 |
Genomic view of the ENSG00000249426 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.