Transcription factors with Perturb-seq knockdown data for ENSG00000249258. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000249258 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000249258, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:16,861,239–16,862,195 | 269.6 kb | Distal (>10kb) Multiome | 98 | |
| chr8:17,000,704–17,002,791 | 129.4 kb | Distal (>10kb) Multiome | 476 | |
| chr8:17,026,598–17,028,107 | 104.0 kb | Distal (>10kb) Multiome | 783 | |
| chr8:17,155,620–17,157,352 | 25.0 kb | Distal (>10kb) Multiome | 722 | |
| chr8:17,185,410–17,186,108 | 54.5 kb | Distal (>10kb) Multiome | 170 | |
| chr8:17,246,012–17,247,955 | 115.4 kb | Distal (>10kb) Multiome | 946 | |
| chr8:17,412,609–17,414,138 | 282.2 kb | Distal (>10kb) Multiome | 371 |
Genomic view of the ENSG00000249258 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.