Transcription factors with Perturb-seq knockdown data for ENSG00000248975. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000248975 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000248975, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:30,291,891–30,292,580 | 4.5 kb | Proximal (<10kb) | 37 | |
| chr14:30,292,854–30,293,141 | 3.9 kb | Proximal (<10kb) | 6 | |
| chr14:30,296,026–30,296,479 | 563 bp | At TSS | 79 | |
| chr14:30,296,978–30,297,198 | at TSS | At TSS | 116 | |
| chr14:30,297,820–30,298,204 | 777 bp | At TSS | 9 | |
| chr14:30,298,444–30,298,967 | 1.4 kb | Proximal (<10kb) | 82 |
Genomic view of the ENSG00000248975 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.